The bis conference series has been running biennially in Rome since 2008. Core goal of the conference is stimulating interest across the basic science-clinical interface. The next conference, bis18, is scheduled for December 13-15, 2018, in Rome. During the past years, the bis conference series have acquired relevance and visibility, and attracted accomplished scientists in the field of cerebrovascular diseases. The congress has reached the status of traditional forum for exchanging ideas and providing updates on cutting-edge research and clinical advancements. The focus of bis18 will be on THE BRAIN-SYSTEMIC AXES, with emphasis on brain interactions with the heart, lung, gut, immune, and endocrine systems.